We have developed a new library of chalcone derivatives of oxazole-pyrimidines (16a-j) and their structures were confirmed by analytical data.Further, in vitro anticancer activity of the newly prepared compounds 16a-j was assessed against Girls Spring Casual Dress a panel of four human cancer cell lines such as human breast cancer (MCF-7), human lung cancer (A549), human colon cancer (Colo-205) and human ovarian cancer (A2780) by using of MTT method.All the screened compounds displayed remarkable anticancer activity as compared with etoposide used as positive control.
Among them, five compounds 16a, Party Range 16 g, 16 h, 16i &16j possessed more potent activity.Particularly, one compound 16j with 3,5-dinitro group showed superior activity.